In Vivo:Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.7 C1GALT1 and Galectin-4 Expression Exhibit a Synergistic Interaction Resulting in Poor Overall Survival Regarding the critical role of C1GALT1 in mediating galectin-4 signaling in CRPC progression, we next examined the clinical correlation of C1GALT1 and galectin-4 in PCa specimens.
Article Title: Cationic lipids and transfection methods
Article Snippet: No. 7,151,086, (SEQ ID NO: 183) Inhibin alpha GeneSeq Accession B02806 WO0020591, P05111/INHA_HUMAN Inhibin alpha chain, (SEQ ID NO: 184) Inhibin beta GeneSeq Accession H02808 WO0020591, P08476/INHBA_HUMAN Inhibin beta A chain, (SEQ ID NO: 185) P09529/INHBB_HUMAN Inhibin beta B chain, (SEQ ID NO: 186) Cerberus Protein GeneSeq Accession W86032 WO9849296, O95813/CER1_HUMAN Cerberus, (SEQ ID NO: 187) Soluble BMP Receptor Kinase Protein- 3 GeneSeq Accession R95227 WO9614579, Q13873/BMPR2_HUMAN Bone morphogenetic proteinreceptor type-2, (SEQ ID NO: 188) BMP Processing Enzyme Furin GeneSeq Accession W36099 WO9741250, P09958/FURIN_HUMAN Furin, (SEQ ID NO: 189) TGF-beta 1 GeneSeq Accession R29657 WO9216228, P01137/TGFB1_HUMAN Transforming growth factor beta-1, (SEQ ID NO: 190) TGF-beta 2 GeneSeq Accession R39659 EP542679, P61812/TGFB2_HUMAN Transforming growth factor beta-2, (SEQ ID NO: 191) ZTGF-beta 9 GeneSeq Accession Y70654 WO0015798, SEQ ID NO: 2 of WO0015798, (SEQ ID NO: 192) Anti-TGF beta family antibodies GB2305921 Latent TGF beta binding protein II GeneSeq Accession Y70552 WO0012551, Q14767/LTBP2_HUMAN Latent-transforming growth factor beta-binding protein 2, (SEQ ID NO: 193) MP52 GeneSeq Accession W36100 WO9741250, P43026/GDF5_HUMAN Growth/differentiation factor 5, (SEQ ID NO: 194) b57 Protein GeneSeq Accession W69293 WO9837195, SEQ ID NO: 2 of WO9837195, (SEQ ID NO: 195) Resistin GeneSeq Accession W69293 WO0064920, Q9HD89/RETN_HUMAN Resistin, (isoform 1), (SEQ ID NO: 196) Galectin-4 GeneSeq Accession W11841 WO9703190, P56470/LEG4_HUMAN Galectin-4, (SEQ ID NO: 197) APM-I; ACRP- 30; Famoxin GeneSeq Accession Y71035 W00026363, Q15848/ADIPO_HUMAN Adiponectin, (SEQ ID NO: 198) ACRP-30 Homologue; Complement Component Clq C GeneSeq Accession B30234 WO0063376, P02747/C1QC_HUMAN Complement C1q subcomponent subunit C, (SEQ ID NO: 199) Calpain-10a GeneSeq Accession Y79567 WO0023603, Q9HC96/CAN10_HUMAN Calpain-10, (isoform A), (SEQ ID NO: 200) Calpain-10b GeneSeq Accession Y79568 WO0023603, Q9HC96-2/CAN10_HUMAN Isoform B of Calpain-10, (SEQ ID NO: 201) Calpain-10c GeneSeq Accession Y79569 WO0023603, Q9HC96-3/CAN10_HUMAN Isoform C of Calpain-10, (SEQ ID NO: 202) PDGF-D GeneSeq Accession Y71130 WO0027879, Q9GZP0/PDGFD_HUMAN Platelet-derived growth factor D, (isoform 1), (SEQ ID NO: 203) FasL GeneSeq Accession Y28594 WO9936079, P48023/TNFL6_HUMAN Tumor necrosis factor ligand superfamily member 6, (isoform 1), (SEQ ID NO: 204) Chondro modulin-like protein GeneSeq Accession Y71262 WO0029579, SEQ ID NO: 2 from WO0029579, (SEQ ID NO: 370) Patched GeneSeq Accession W72969 U.S. Pat.
Article Title: Research progress of galectins in glioma.
Article Snippet: :(0123456789) Galectins, which consist of a single polypeptide chain with two CRDs connected by a linker peptide (Galectin-4, -6, -8, -9, and -12); and chimeric Galectin-3, which has a C-terminal CRD rich in proline and glycine and an N-terminal domain that can mediate oligomerization, mainly trimers and pentamers [16].
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.5 Galectin-4/0-Glycan Signaling Promotes SOX9 Expression, Cancer Cell Stemness Properties, and Metastasis Via Activation of RTKs To understand the mechanisms of galectin/glycan signaling for metastasis, we analyzed the genome-wide responsive genes using cDNA microarray by comparing ectopic expression of galectin-4 and control vector in parental cells, LNCaP and 22Rv1, or control and galectin-4 knockdown conditions in 22Rv1-M4 expressing a high level of galectin-4.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: Galectin-4 or LGALS4 NCBI Gene ID: 3960.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.6 Galectin-4 Feed-Forward Upregulates its Binding Sites and Downstream Signaling by Altering the Specific O-Glycosylation Pathway Since galectin-4/SOX9 signaling is dependent on C1GALT1-mediated O-glycosylation and the concomitant overexpression along with PCa progression; we next investigated whether expression of galectin-4, C1GALT1 and protein O-glycosylation may be mutually regulated.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.4 Galectin-4/O-Glycan Signaling Promotes not Only Castration-Resistant Growth but Also Metastasis In Vivo In vivo, downregulation of galectin-4 sensitized the LNCaP-CR4 tumors to castration treatment compared to LNCaP-CR4 control tumors by inhibiting primary tumor growth and lymph node metastasis, suggesting the castration-resistant growth of LNCaP-CR4 had galectin-4 signaling activity (FIG. 4A-C).
Control:Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.7 C1GALT1 and Galectin-4 Expression Exhibit a Synergistic Interaction Resulting in Poor Overall Survival Regarding the critical role of C1GALT1 in mediating galectin-4 signaling in CRPC progression, we next examined the clinical correlation of C1GALT1 and galectin-4 in PCa specimens.
Article Title: Cationic lipids and transfection methods
Article Snippet: No. 7,151,086, (SEQ ID NO: 183) Inhibin alpha GeneSeq Accession B02806 WO0020591, P05111/INHA_HUMAN Inhibin alpha chain, (SEQ ID NO: 184) Inhibin beta GeneSeq Accession H02808 WO0020591, P08476/INHBA_HUMAN Inhibin beta A chain, (SEQ ID NO: 185) P09529/INHBB_HUMAN Inhibin beta B chain, (SEQ ID NO: 186) Cerberus Protein GeneSeq Accession W86032 WO9849296, O95813/CER1_HUMAN Cerberus, (SEQ ID NO: 187) Soluble BMP Receptor Kinase Protein- 3 GeneSeq Accession R95227 WO9614579, Q13873/BMPR2_HUMAN Bone morphogenetic proteinreceptor type-2, (SEQ ID NO: 188) BMP Processing Enzyme Furin GeneSeq Accession W36099 WO9741250, P09958/FURIN_HUMAN Furin, (SEQ ID NO: 189) TGF-beta 1 GeneSeq Accession R29657 WO9216228, P01137/TGFB1_HUMAN Transforming growth factor beta-1, (SEQ ID NO: 190) TGF-beta 2 GeneSeq Accession R39659 EP542679, P61812/TGFB2_HUMAN Transforming growth factor beta-2, (SEQ ID NO: 191) ZTGF-beta 9 GeneSeq Accession Y70654 WO0015798, SEQ ID NO: 2 of WO0015798, (SEQ ID NO: 192) Anti-TGF beta family antibodies GB2305921 Latent TGF beta binding protein II GeneSeq Accession Y70552 WO0012551, Q14767/LTBP2_HUMAN Latent-transforming growth factor beta-binding protein 2, (SEQ ID NO: 193) MP52 GeneSeq Accession W36100 WO9741250, P43026/GDF5_HUMAN Growth/differentiation factor 5, (SEQ ID NO: 194) b57 Protein GeneSeq Accession W69293 WO9837195, SEQ ID NO: 2 of WO9837195, (SEQ ID NO: 195) Resistin GeneSeq Accession W69293 WO0064920, Q9HD89/RETN_HUMAN Resistin, (isoform 1), (SEQ ID NO: 196) Galectin-4 GeneSeq Accession W11841 WO9703190, P56470/LEG4_HUMAN Galectin-4, (SEQ ID NO: 197) APM-I; ACRP- 30; Famoxin GeneSeq Accession Y71035 W00026363, Q15848/ADIPO_HUMAN Adiponectin, (SEQ ID NO: 198) ACRP-30 Homologue; Complement Component Clq C GeneSeq Accession B30234 WO0063376, P02747/C1QC_HUMAN Complement C1q subcomponent subunit C, (SEQ ID NO: 199) Calpain-10a GeneSeq Accession Y79567 WO0023603, Q9HC96/CAN10_HUMAN Calpain-10, (isoform A), (SEQ ID NO: 200) Calpain-10b GeneSeq Accession Y79568 WO0023603, Q9HC96-2/CAN10_HUMAN Isoform B of Calpain-10, (SEQ ID NO: 201) Calpain-10c GeneSeq Accession Y79569 WO0023603, Q9HC96-3/CAN10_HUMAN Isoform C of Calpain-10, (SEQ ID NO: 202) PDGF-D GeneSeq Accession Y71130 WO0027879, Q9GZP0/PDGFD_HUMAN Platelet-derived growth factor D, (isoform 1), (SEQ ID NO: 203) FasL GeneSeq Accession Y28594 WO9936079, P48023/TNFL6_HUMAN Tumor necrosis factor ligand superfamily member 6, (isoform 1), (SEQ ID NO: 204) Chondro modulin-like protein GeneSeq Accession Y71262 WO0029579, SEQ ID NO: 2 from WO0029579, (SEQ ID NO: 370) Patched GeneSeq Accession W72969 U.S. Pat.
Article Title: Research progress of galectins in glioma.
Article Snippet: :(0123456789) Galectins, which consist of a single polypeptide chain with two CRDs connected by a linker peptide (Galectin-4, -6, -8, -9, and -12); and chimeric Galectin-3, which has a C-terminal CRD rich in proline and glycine and an N-terminal domain that can mediate oligomerization, mainly trimers and pentamers [16].
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.5 Galectin-4/0-Glycan Signaling Promotes SOX9 Expression, Cancer Cell Stemness Properties, and Metastasis Via Activation of RTKs To understand the mechanisms of galectin/glycan signaling for metastasis, we analyzed the genome-wide responsive genes using cDNA microarray by comparing ectopic expression of galectin-4 and control vector in parental cells, LNCaP and 22Rv1, or control and galectin-4 knockdown conditions in 22Rv1-M4 expressing a high level of galectin-4.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: Galectin-4 or LGALS4 NCBI Gene ID: 3960.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.6 Galectin-4 Feed-Forward Upregulates its Binding Sites and Downstream Signaling by Altering the Specific O-Glycosylation Pathway Since galectin-4/SOX9 signaling is dependent on C1GALT1-mediated O-glycosylation and the concomitant overexpression along with PCa progression; we next investigated whether expression of galectin-4, C1GALT1 and protein O-glycosylation may be mutually regulated.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.4 Galectin-4/O-Glycan Signaling Promotes not Only Castration-Resistant Growth but Also Metastasis In Vivo In vivo, downregulation of galectin-4 sensitized the LNCaP-CR4 tumors to castration treatment compared to LNCaP-CR4 control tumors by inhibiting primary tumor growth and lymph node metastasis, suggesting the castration-resistant growth of LNCaP-CR4 had galectin-4 signaling activity (FIG. 4A-C).
Activity Assay:Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.7 C1GALT1 and Galectin-4 Expression Exhibit a Synergistic Interaction Resulting in Poor Overall Survival Regarding the critical role of C1GALT1 in mediating galectin-4 signaling in CRPC progression, we next examined the clinical correlation of C1GALT1 and galectin-4 in PCa specimens.
Article Title: Cationic lipids and transfection methods
Article Snippet: No. 7,151,086, (SEQ ID NO: 183) Inhibin alpha GeneSeq Accession B02806 WO0020591, P05111/INHA_HUMAN Inhibin alpha chain, (SEQ ID NO: 184) Inhibin beta GeneSeq Accession H02808 WO0020591, P08476/INHBA_HUMAN Inhibin beta A chain, (SEQ ID NO: 185) P09529/INHBB_HUMAN Inhibin beta B chain, (SEQ ID NO: 186) Cerberus Protein GeneSeq Accession W86032 WO9849296, O95813/CER1_HUMAN Cerberus, (SEQ ID NO: 187) Soluble BMP Receptor Kinase Protein- 3 GeneSeq Accession R95227 WO9614579, Q13873/BMPR2_HUMAN Bone morphogenetic proteinreceptor type-2, (SEQ ID NO: 188) BMP Processing Enzyme Furin GeneSeq Accession W36099 WO9741250, P09958/FURIN_HUMAN Furin, (SEQ ID NO: 189) TGF-beta 1 GeneSeq Accession R29657 WO9216228, P01137/TGFB1_HUMAN Transforming growth factor beta-1, (SEQ ID NO: 190) TGF-beta 2 GeneSeq Accession R39659 EP542679, P61812/TGFB2_HUMAN Transforming growth factor beta-2, (SEQ ID NO: 191) ZTGF-beta 9 GeneSeq Accession Y70654 WO0015798, SEQ ID NO: 2 of WO0015798, (SEQ ID NO: 192) Anti-TGF beta family antibodies GB2305921 Latent TGF beta binding protein II GeneSeq Accession Y70552 WO0012551, Q14767/LTBP2_HUMAN Latent-transforming growth factor beta-binding protein 2, (SEQ ID NO: 193) MP52 GeneSeq Accession W36100 WO9741250, P43026/GDF5_HUMAN Growth/differentiation factor 5, (SEQ ID NO: 194) b57 Protein GeneSeq Accession W69293 WO9837195, SEQ ID NO: 2 of WO9837195, (SEQ ID NO: 195) Resistin GeneSeq Accession W69293 WO0064920, Q9HD89/RETN_HUMAN Resistin, (isoform 1), (SEQ ID NO: 196) Galectin-4 GeneSeq Accession W11841 WO9703190, P56470/LEG4_HUMAN Galectin-4, (SEQ ID NO: 197) APM-I; ACRP- 30; Famoxin GeneSeq Accession Y71035 W00026363, Q15848/ADIPO_HUMAN Adiponectin, (SEQ ID NO: 198) ACRP-30 Homologue; Complement Component Clq C GeneSeq Accession B30234 WO0063376, P02747/C1QC_HUMAN Complement C1q subcomponent subunit C, (SEQ ID NO: 199) Calpain-10a GeneSeq Accession Y79567 WO0023603, Q9HC96/CAN10_HUMAN Calpain-10, (isoform A), (SEQ ID NO: 200) Calpain-10b GeneSeq Accession Y79568 WO0023603, Q9HC96-2/CAN10_HUMAN Isoform B of Calpain-10, (SEQ ID NO: 201) Calpain-10c GeneSeq Accession Y79569 WO0023603, Q9HC96-3/CAN10_HUMAN Isoform C of Calpain-10, (SEQ ID NO: 202) PDGF-D GeneSeq Accession Y71130 WO0027879, Q9GZP0/PDGFD_HUMAN Platelet-derived growth factor D, (isoform 1), (SEQ ID NO: 203) FasL GeneSeq Accession Y28594 WO9936079, P48023/TNFL6_HUMAN Tumor necrosis factor ligand superfamily member 6, (isoform 1), (SEQ ID NO: 204) Chondro modulin-like protein GeneSeq Accession Y71262 WO0029579, SEQ ID NO: 2 from WO0029579, (SEQ ID NO: 370) Patched GeneSeq Accession W72969 U.S. Pat.
Article Title: Research progress of galectins in glioma.
Article Snippet: :(0123456789) Galectins, which consist of a single polypeptide chain with two CRDs connected by a linker peptide (Galectin-4, -6, -8, -9, and -12); and chimeric Galectin-3, which has a C-terminal CRD rich in proline and glycine and an N-terminal domain that can mediate oligomerization, mainly trimers and pentamers [16].
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.5 Galectin-4/0-Glycan Signaling Promotes SOX9 Expression, Cancer Cell Stemness Properties, and Metastasis Via Activation of RTKs To understand the mechanisms of galectin/glycan signaling for metastasis, we analyzed the genome-wide responsive genes using cDNA microarray by comparing ectopic expression of galectin-4 and control vector in parental cells, LNCaP and 22Rv1, or control and galectin-4 knockdown conditions in 22Rv1-M4 expressing a high level of galectin-4.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: Galectin-4 or LGALS4 NCBI Gene ID: 3960.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.6 Galectin-4 Feed-Forward Upregulates its Binding Sites and Downstream Signaling by Altering the Specific O-Glycosylation Pathway Since galectin-4/SOX9 signaling is dependent on C1GALT1-mediated O-glycosylation and the concomitant overexpression along with PCa progression; we next investigated whether expression of galectin-4, C1GALT1 and protein O-glycosylation may be mutually regulated.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.4 Galectin-4/O-Glycan Signaling Promotes not Only Castration-Resistant Growth but Also Metastasis In Vivo In vivo, downregulation of galectin-4 sensitized the LNCaP-CR4 tumors to castration treatment compared to LNCaP-CR4 control tumors by inhibiting primary tumor growth and lymph node metastasis, suggesting the castration-resistant growth of LNCaP-CR4 had galectin-4 signaling activity (FIG. 4A-C).
Expressing:Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.7 C1GALT1 and Galectin-4 Expression Exhibit a Synergistic Interaction Resulting in Poor Overall Survival Regarding the critical role of C1GALT1 in mediating galectin-4 signaling in CRPC progression, we next examined the clinical correlation of C1GALT1 and galectin-4 in PCa specimens.
Article Title: Cationic lipids and transfection methods
Article Snippet: No. 7,151,086, (SEQ ID NO: 183) Inhibin alpha GeneSeq Accession B02806 WO0020591, P05111/INHA_HUMAN Inhibin alpha chain, (SEQ ID NO: 184) Inhibin beta GeneSeq Accession H02808 WO0020591, P08476/INHBA_HUMAN Inhibin beta A chain, (SEQ ID NO: 185) P09529/INHBB_HUMAN Inhibin beta B chain, (SEQ ID NO: 186) Cerberus Protein GeneSeq Accession W86032 WO9849296, O95813/CER1_HUMAN Cerberus, (SEQ ID NO: 187) Soluble BMP Receptor Kinase Protein- 3 GeneSeq Accession R95227 WO9614579, Q13873/BMPR2_HUMAN Bone morphogenetic proteinreceptor type-2, (SEQ ID NO: 188) BMP Processing Enzyme Furin GeneSeq Accession W36099 WO9741250, P09958/FURIN_HUMAN Furin, (SEQ ID NO: 189) TGF-beta 1 GeneSeq Accession R29657 WO9216228, P01137/TGFB1_HUMAN Transforming growth factor beta-1, (SEQ ID NO: 190) TGF-beta 2 GeneSeq Accession R39659 EP542679, P61812/TGFB2_HUMAN Transforming growth factor beta-2, (SEQ ID NO: 191) ZTGF-beta 9 GeneSeq Accession Y70654 WO0015798, SEQ ID NO: 2 of WO0015798, (SEQ ID NO: 192) Anti-TGF beta family antibodies GB2305921 Latent TGF beta binding protein II GeneSeq Accession Y70552 WO0012551, Q14767/LTBP2_HUMAN Latent-transforming growth factor beta-binding protein 2, (SEQ ID NO: 193) MP52 GeneSeq Accession W36100 WO9741250, P43026/GDF5_HUMAN Growth/differentiation factor 5, (SEQ ID NO: 194) b57 Protein GeneSeq Accession W69293 WO9837195, SEQ ID NO: 2 of WO9837195, (SEQ ID NO: 195) Resistin GeneSeq Accession W69293 WO0064920, Q9HD89/RETN_HUMAN Resistin, (isoform 1), (SEQ ID NO: 196) Galectin-4 GeneSeq Accession W11841 WO9703190, P56470/LEG4_HUMAN Galectin-4, (SEQ ID NO: 197) APM-I; ACRP- 30; Famoxin GeneSeq Accession Y71035 W00026363, Q15848/ADIPO_HUMAN Adiponectin, (SEQ ID NO: 198) ACRP-30 Homologue; Complement Component Clq C GeneSeq Accession B30234 WO0063376, P02747/C1QC_HUMAN Complement C1q subcomponent subunit C, (SEQ ID NO: 199) Calpain-10a GeneSeq Accession Y79567 WO0023603, Q9HC96/CAN10_HUMAN Calpain-10, (isoform A), (SEQ ID NO: 200) Calpain-10b GeneSeq Accession Y79568 WO0023603, Q9HC96-2/CAN10_HUMAN Isoform B of Calpain-10, (SEQ ID NO: 201) Calpain-10c GeneSeq Accession Y79569 WO0023603, Q9HC96-3/CAN10_HUMAN Isoform C of Calpain-10, (SEQ ID NO: 202) PDGF-D GeneSeq Accession Y71130 WO0027879, Q9GZP0/PDGFD_HUMAN Platelet-derived growth factor D, (isoform 1), (SEQ ID NO: 203) FasL GeneSeq Accession Y28594 WO9936079, P48023/TNFL6_HUMAN Tumor necrosis factor ligand superfamily member 6, (isoform 1), (SEQ ID NO: 204) Chondro modulin-like protein GeneSeq Accession Y71262 WO0029579, SEQ ID NO: 2 from WO0029579, (SEQ ID NO: 370) Patched GeneSeq Accession W72969 U.S. Pat.
Article Title: Research progress of galectins in glioma.
Article Snippet: :(0123456789) Galectins, which consist of a single polypeptide chain with two CRDs connected by a linker peptide (Galectin-4, -6, -8, -9, and -12); and chimeric Galectin-3, which has a C-terminal CRD rich in proline and glycine and an N-terminal domain that can mediate oligomerization, mainly trimers and pentamers [16].
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.5 Galectin-4/0-Glycan Signaling Promotes SOX9 Expression, Cancer Cell Stemness Properties, and Metastasis Via Activation of RTKs To understand the mechanisms of galectin/glycan signaling for metastasis, we analyzed the genome-wide responsive genes using cDNA microarray by comparing ectopic expression of galectin-4 and control vector in parental cells, LNCaP and 22Rv1, or control and galectin-4 knockdown conditions in 22Rv1-M4 expressing a high level of galectin-4.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: Galectin-4 or LGALS4 NCBI Gene ID: 3960.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.6 Galectin-4 Feed-Forward Upregulates its Binding Sites and Downstream Signaling by Altering the Specific O-Glycosylation Pathway Since galectin-4/SOX9 signaling is dependent on C1GALT1-mediated O-glycosylation and the concomitant overexpression along with PCa progression; we next investigated whether expression of galectin-4, C1GALT1 and protein O-glycosylation may be mutually regulated.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.4 Galectin-4/O-Glycan Signaling Promotes not Only Castration-Resistant Growth but Also Metastasis In Vivo In vivo, downregulation of galectin-4 sensitized the LNCaP-CR4 tumors to castration treatment compared to LNCaP-CR4 control tumors by inhibiting primary tumor growth and lymph node metastasis, suggesting the castration-resistant growth of LNCaP-CR4 had galectin-4 signaling activity (FIG. 4A-C).
Activation Assay:Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.7 C1GALT1 and Galectin-4 Expression Exhibit a Synergistic Interaction Resulting in Poor Overall Survival Regarding the critical role of C1GALT1 in mediating galectin-4 signaling in CRPC progression, we next examined the clinical correlation of C1GALT1 and galectin-4 in PCa specimens.
Article Title: Cationic lipids and transfection methods
Article Snippet: No. 7,151,086, (SEQ ID NO: 183) Inhibin alpha GeneSeq Accession B02806 WO0020591, P05111/INHA_HUMAN Inhibin alpha chain, (SEQ ID NO: 184) Inhibin beta GeneSeq Accession H02808 WO0020591, P08476/INHBA_HUMAN Inhibin beta A chain, (SEQ ID NO: 185) P09529/INHBB_HUMAN Inhibin beta B chain, (SEQ ID NO: 186) Cerberus Protein GeneSeq Accession W86032 WO9849296, O95813/CER1_HUMAN Cerberus, (SEQ ID NO: 187) Soluble BMP Receptor Kinase Protein- 3 GeneSeq Accession R95227 WO9614579, Q13873/BMPR2_HUMAN Bone morphogenetic proteinreceptor type-2, (SEQ ID NO: 188) BMP Processing Enzyme Furin GeneSeq Accession W36099 WO9741250, P09958/FURIN_HUMAN Furin, (SEQ ID NO: 189) TGF-beta 1 GeneSeq Accession R29657 WO9216228, P01137/TGFB1_HUMAN Transforming growth factor beta-1, (SEQ ID NO: 190) TGF-beta 2 GeneSeq Accession R39659 EP542679, P61812/TGFB2_HUMAN Transforming growth factor beta-2, (SEQ ID NO: 191) ZTGF-beta 9 GeneSeq Accession Y70654 WO0015798, SEQ ID NO: 2 of WO0015798, (SEQ ID NO: 192) Anti-TGF beta family antibodies GB2305921 Latent TGF beta binding protein II GeneSeq Accession Y70552 WO0012551, Q14767/LTBP2_HUMAN Latent-transforming growth factor beta-binding protein 2, (SEQ ID NO: 193) MP52 GeneSeq Accession W36100 WO9741250, P43026/GDF5_HUMAN Growth/differentiation factor 5, (SEQ ID NO: 194) b57 Protein GeneSeq Accession W69293 WO9837195, SEQ ID NO: 2 of WO9837195, (SEQ ID NO: 195) Resistin GeneSeq Accession W69293 WO0064920, Q9HD89/RETN_HUMAN Resistin, (isoform 1), (SEQ ID NO: 196) Galectin-4 GeneSeq Accession W11841 WO9703190, P56470/LEG4_HUMAN Galectin-4, (SEQ ID NO: 197) APM-I; ACRP- 30; Famoxin GeneSeq Accession Y71035 W00026363, Q15848/ADIPO_HUMAN Adiponectin, (SEQ ID NO: 198) ACRP-30 Homologue; Complement Component Clq C GeneSeq Accession B30234 WO0063376, P02747/C1QC_HUMAN Complement C1q subcomponent subunit C, (SEQ ID NO: 199) Calpain-10a GeneSeq Accession Y79567 WO0023603, Q9HC96/CAN10_HUMAN Calpain-10, (isoform A), (SEQ ID NO: 200) Calpain-10b GeneSeq Accession Y79568 WO0023603, Q9HC96-2/CAN10_HUMAN Isoform B of Calpain-10, (SEQ ID NO: 201) Calpain-10c GeneSeq Accession Y79569 WO0023603, Q9HC96-3/CAN10_HUMAN Isoform C of Calpain-10, (SEQ ID NO: 202) PDGF-D GeneSeq Accession Y71130 WO0027879, Q9GZP0/PDGFD_HUMAN Platelet-derived growth factor D, (isoform 1), (SEQ ID NO: 203) FasL GeneSeq Accession Y28594 WO9936079, P48023/TNFL6_HUMAN Tumor necrosis factor ligand superfamily member 6, (isoform 1), (SEQ ID NO: 204) Chondro modulin-like protein GeneSeq Accession Y71262 WO0029579, SEQ ID NO: 2 from WO0029579, (SEQ ID NO: 370) Patched GeneSeq Accession W72969 U.S. Pat.
Article Title: Research progress of galectins in glioma.
Article Snippet: :(0123456789) Galectins, which consist of a single polypeptide chain with two CRDs connected by a linker peptide (Galectin-4, -6, -8, -9, and -12); and chimeric Galectin-3, which has a C-terminal CRD rich in proline and glycine and an N-terminal domain that can mediate oligomerization, mainly trimers and pentamers [16].
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.5 Galectin-4/0-Glycan Signaling Promotes SOX9 Expression, Cancer Cell Stemness Properties, and Metastasis Via Activation of RTKs To understand the mechanisms of galectin/glycan signaling for metastasis, we analyzed the genome-wide responsive genes using cDNA microarray by comparing ectopic expression of galectin-4 and control vector in parental cells, LNCaP and 22Rv1, or control and galectin-4 knockdown conditions in 22Rv1-M4 expressing a high level of galectin-4.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: Galectin-4 or LGALS4 NCBI Gene ID: 3960.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.6 Galectin-4 Feed-Forward Upregulates its Binding Sites and Downstream Signaling by Altering the Specific O-Glycosylation Pathway Since galectin-4/SOX9 signaling is dependent on C1GALT1-mediated O-glycosylation and the concomitant overexpression along with PCa progression; we next investigated whether expression of galectin-4, C1GALT1 and protein O-glycosylation may be mutually regulated.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.4 Galectin-4/O-Glycan Signaling Promotes not Only Castration-Resistant Growth but Also Metastasis In Vivo In vivo, downregulation of galectin-4 sensitized the LNCaP-CR4 tumors to castration treatment compared to LNCaP-CR4 control tumors by inhibiting primary tumor growth and lymph node metastasis, suggesting the castration-resistant growth of LNCaP-CR4 had galectin-4 signaling activity (FIG. 4A-C).
Genome Wide:Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.7 C1GALT1 and Galectin-4 Expression Exhibit a Synergistic Interaction Resulting in Poor Overall Survival Regarding the critical role of C1GALT1 in mediating galectin-4 signaling in CRPC progression, we next examined the clinical correlation of C1GALT1 and galectin-4 in PCa specimens.
Article Title: Cationic lipids and transfection methods
Article Snippet: No. 7,151,086, (SEQ ID NO: 183) Inhibin alpha GeneSeq Accession B02806 WO0020591, P05111/INHA_HUMAN Inhibin alpha chain, (SEQ ID NO: 184) Inhibin beta GeneSeq Accession H02808 WO0020591, P08476/INHBA_HUMAN Inhibin beta A chain, (SEQ ID NO: 185) P09529/INHBB_HUMAN Inhibin beta B chain, (SEQ ID NO: 186) Cerberus Protein GeneSeq Accession W86032 WO9849296, O95813/CER1_HUMAN Cerberus, (SEQ ID NO: 187) Soluble BMP Receptor Kinase Protein- 3 GeneSeq Accession R95227 WO9614579, Q13873/BMPR2_HUMAN Bone morphogenetic proteinreceptor type-2, (SEQ ID NO: 188) BMP Processing Enzyme Furin GeneSeq Accession W36099 WO9741250, P09958/FURIN_HUMAN Furin, (SEQ ID NO: 189) TGF-beta 1 GeneSeq Accession R29657 WO9216228, P01137/TGFB1_HUMAN Transforming growth factor beta-1, (SEQ ID NO: 190) TGF-beta 2 GeneSeq Accession R39659 EP542679, P61812/TGFB2_HUMAN Transforming growth factor beta-2, (SEQ ID NO: 191) ZTGF-beta 9 GeneSeq Accession Y70654 WO0015798, SEQ ID NO: 2 of WO0015798, (SEQ ID NO: 192) Anti-TGF beta family antibodies GB2305921 Latent TGF beta binding protein II GeneSeq Accession Y70552 WO0012551, Q14767/LTBP2_HUMAN Latent-transforming growth factor beta-binding protein 2, (SEQ ID NO: 193) MP52 GeneSeq Accession W36100 WO9741250, P43026/GDF5_HUMAN Growth/differentiation factor 5, (SEQ ID NO: 194) b57 Protein GeneSeq Accession W69293 WO9837195, SEQ ID NO: 2 of WO9837195, (SEQ ID NO: 195) Resistin GeneSeq Accession W69293 WO0064920, Q9HD89/RETN_HUMAN Resistin, (isoform 1), (SEQ ID NO: 196) Galectin-4 GeneSeq Accession W11841 WO9703190, P56470/LEG4_HUMAN Galectin-4, (SEQ ID NO: 197) APM-I; ACRP- 30; Famoxin GeneSeq Accession Y71035 W00026363, Q15848/ADIPO_HUMAN Adiponectin, (SEQ ID NO: 198) ACRP-30 Homologue; Complement Component Clq C GeneSeq Accession B30234 WO0063376, P02747/C1QC_HUMAN Complement C1q subcomponent subunit C, (SEQ ID NO: 199) Calpain-10a GeneSeq Accession Y79567 WO0023603, Q9HC96/CAN10_HUMAN Calpain-10, (isoform A), (SEQ ID NO: 200) Calpain-10b GeneSeq Accession Y79568 WO0023603, Q9HC96-2/CAN10_HUMAN Isoform B of Calpain-10, (SEQ ID NO: 201) Calpain-10c GeneSeq Accession Y79569 WO0023603, Q9HC96-3/CAN10_HUMAN Isoform C of Calpain-10, (SEQ ID NO: 202) PDGF-D GeneSeq Accession Y71130 WO0027879, Q9GZP0/PDGFD_HUMAN Platelet-derived growth factor D, (isoform 1), (SEQ ID NO: 203) FasL GeneSeq Accession Y28594 WO9936079, P48023/TNFL6_HUMAN Tumor necrosis factor ligand superfamily member 6, (isoform 1), (SEQ ID NO: 204) Chondro modulin-like protein GeneSeq Accession Y71262 WO0029579, SEQ ID NO: 2 from WO0029579, (SEQ ID NO: 370) Patched GeneSeq Accession W72969 U.S. Pat.
Article Title: Research progress of galectins in glioma.
Article Snippet: :(0123456789) Galectins, which consist of a single polypeptide chain with two CRDs connected by a linker peptide (Galectin-4, -6, -8, -9, and -12); and chimeric Galectin-3, which has a C-terminal CRD rich in proline and glycine and an N-terminal domain that can mediate oligomerization, mainly trimers and pentamers [16].
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.5 Galectin-4/0-Glycan Signaling Promotes SOX9 Expression, Cancer Cell Stemness Properties, and Metastasis Via Activation of RTKs To understand the mechanisms of galectin/glycan signaling for metastasis, we analyzed the genome-wide responsive genes using cDNA microarray by comparing ectopic expression of galectin-4 and control vector in parental cells, LNCaP and 22Rv1, or control and galectin-4 knockdown conditions in 22Rv1-M4 expressing a high level of galectin-4.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: Galectin-4 or LGALS4 NCBI Gene ID: 3960.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.6 Galectin-4 Feed-Forward Upregulates its Binding Sites and Downstream Signaling by Altering the Specific O-Glycosylation Pathway Since galectin-4/SOX9 signaling is dependent on C1GALT1-mediated O-glycosylation and the concomitant overexpression along with PCa progression; we next investigated whether expression of galectin-4, C1GALT1 and protein O-glycosylation may be mutually regulated.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.4 Galectin-4/O-Glycan Signaling Promotes not Only Castration-Resistant Growth but Also Metastasis In Vivo In vivo, downregulation of galectin-4 sensitized the LNCaP-CR4 tumors to castration treatment compared to LNCaP-CR4 control tumors by inhibiting primary tumor growth and lymph node metastasis, suggesting the castration-resistant growth of LNCaP-CR4 had galectin-4 signaling activity (FIG. 4A-C).
Microarray:Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.7 C1GALT1 and Galectin-4 Expression Exhibit a Synergistic Interaction Resulting in Poor Overall Survival Regarding the critical role of C1GALT1 in mediating galectin-4 signaling in CRPC progression, we next examined the clinical correlation of C1GALT1 and galectin-4 in PCa specimens.
Article Title: Cationic lipids and transfection methods
Article Snippet: No. 7,151,086, (SEQ ID NO: 183) Inhibin alpha GeneSeq Accession B02806 WO0020591, P05111/INHA_HUMAN Inhibin alpha chain, (SEQ ID NO: 184) Inhibin beta GeneSeq Accession H02808 WO0020591, P08476/INHBA_HUMAN Inhibin beta A chain, (SEQ ID NO: 185) P09529/INHBB_HUMAN Inhibin beta B chain, (SEQ ID NO: 186) Cerberus Protein GeneSeq Accession W86032 WO9849296, O95813/CER1_HUMAN Cerberus, (SEQ ID NO: 187) Soluble BMP Receptor Kinase Protein- 3 GeneSeq Accession R95227 WO9614579, Q13873/BMPR2_HUMAN Bone morphogenetic proteinreceptor type-2, (SEQ ID NO: 188) BMP Processing Enzyme Furin GeneSeq Accession W36099 WO9741250, P09958/FURIN_HUMAN Furin, (SEQ ID NO: 189) TGF-beta 1 GeneSeq Accession R29657 WO9216228, P01137/TGFB1_HUMAN Transforming growth factor beta-1, (SEQ ID NO: 190) TGF-beta 2 GeneSeq Accession R39659 EP542679, P61812/TGFB2_HUMAN Transforming growth factor beta-2, (SEQ ID NO: 191) ZTGF-beta 9 GeneSeq Accession Y70654 WO0015798, SEQ ID NO: 2 of WO0015798, (SEQ ID NO: 192) Anti-TGF beta family antibodies GB2305921 Latent TGF beta binding protein II GeneSeq Accession Y70552 WO0012551, Q14767/LTBP2_HUMAN Latent-transforming growth factor beta-binding protein 2, (SEQ ID NO: 193) MP52 GeneSeq Accession W36100 WO9741250, P43026/GDF5_HUMAN Growth/differentiation factor 5, (SEQ ID NO: 194) b57 Protein GeneSeq Accession W69293 WO9837195, SEQ ID NO: 2 of WO9837195, (SEQ ID NO: 195) Resistin GeneSeq Accession W69293 WO0064920, Q9HD89/RETN_HUMAN Resistin, (isoform 1), (SEQ ID NO: 196) Galectin-4 GeneSeq Accession W11841 WO9703190, P56470/LEG4_HUMAN Galectin-4, (SEQ ID NO: 197) APM-I; ACRP- 30; Famoxin GeneSeq Accession Y71035 W00026363, Q15848/ADIPO_HUMAN Adiponectin, (SEQ ID NO: 198) ACRP-30 Homologue; Complement Component Clq C GeneSeq Accession B30234 WO0063376, P02747/C1QC_HUMAN Complement C1q subcomponent subunit C, (SEQ ID NO: 199) Calpain-10a GeneSeq Accession Y79567 WO0023603, Q9HC96/CAN10_HUMAN Calpain-10, (isoform A), (SEQ ID NO: 200) Calpain-10b GeneSeq Accession Y79568 WO0023603, Q9HC96-2/CAN10_HUMAN Isoform B of Calpain-10, (SEQ ID NO: 201) Calpain-10c GeneSeq Accession Y79569 WO0023603, Q9HC96-3/CAN10_HUMAN Isoform C of Calpain-10, (SEQ ID NO: 202) PDGF-D GeneSeq Accession Y71130 WO0027879, Q9GZP0/PDGFD_HUMAN Platelet-derived growth factor D, (isoform 1), (SEQ ID NO: 203) FasL GeneSeq Accession Y28594 WO9936079, P48023/TNFL6_HUMAN Tumor necrosis factor ligand superfamily member 6, (isoform 1), (SEQ ID NO: 204) Chondro modulin-like protein GeneSeq Accession Y71262 WO0029579, SEQ ID NO: 2 from WO0029579, (SEQ ID NO: 370) Patched GeneSeq Accession W72969 U.S. Pat.
Article Title: Research progress of galectins in glioma.
Article Snippet: :(0123456789) Galectins, which consist of a single polypeptide chain with two CRDs connected by a linker peptide (Galectin-4, -6, -8, -9, and -12); and chimeric Galectin-3, which has a C-terminal CRD rich in proline and glycine and an N-terminal domain that can mediate oligomerization, mainly trimers and pentamers [16].
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.5 Galectin-4/0-Glycan Signaling Promotes SOX9 Expression, Cancer Cell Stemness Properties, and Metastasis Via Activation of RTKs To understand the mechanisms of galectin/glycan signaling for metastasis, we analyzed the genome-wide responsive genes using cDNA microarray by comparing ectopic expression of galectin-4 and control vector in parental cells, LNCaP and 22Rv1, or control and galectin-4 knockdown conditions in 22Rv1-M4 expressing a high level of galectin-4.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: Galectin-4 or LGALS4 NCBI Gene ID: 3960.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.6 Galectin-4 Feed-Forward Upregulates its Binding Sites and Downstream Signaling by Altering the Specific O-Glycosylation Pathway Since galectin-4/SOX9 signaling is dependent on C1GALT1-mediated O-glycosylation and the concomitant overexpression along with PCa progression; we next investigated whether expression of galectin-4, C1GALT1 and protein O-glycosylation may be mutually regulated.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.4 Galectin-4/O-Glycan Signaling Promotes not Only Castration-Resistant Growth but Also Metastasis In Vivo In vivo, downregulation of galectin-4 sensitized the LNCaP-CR4 tumors to castration treatment compared to LNCaP-CR4 control tumors by inhibiting primary tumor growth and lymph node metastasis, suggesting the castration-resistant growth of LNCaP-CR4 had galectin-4 signaling activity (FIG. 4A-C).
Plasmid Preparation:Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.7 C1GALT1 and Galectin-4 Expression Exhibit a Synergistic Interaction Resulting in Poor Overall Survival Regarding the critical role of C1GALT1 in mediating galectin-4 signaling in CRPC progression, we next examined the clinical correlation of C1GALT1 and galectin-4 in PCa specimens.
Article Title: Cationic lipids and transfection methods
Article Snippet: No. 7,151,086, (SEQ ID NO: 183) Inhibin alpha GeneSeq Accession B02806 WO0020591, P05111/INHA_HUMAN Inhibin alpha chain, (SEQ ID NO: 184) Inhibin beta GeneSeq Accession H02808 WO0020591, P08476/INHBA_HUMAN Inhibin beta A chain, (SEQ ID NO: 185) P09529/INHBB_HUMAN Inhibin beta B chain, (SEQ ID NO: 186) Cerberus Protein GeneSeq Accession W86032 WO9849296, O95813/CER1_HUMAN Cerberus, (SEQ ID NO: 187) Soluble BMP Receptor Kinase Protein- 3 GeneSeq Accession R95227 WO9614579, Q13873/BMPR2_HUMAN Bone morphogenetic proteinreceptor type-2, (SEQ ID NO: 188) BMP Processing Enzyme Furin GeneSeq Accession W36099 WO9741250, P09958/FURIN_HUMAN Furin, (SEQ ID NO: 189) TGF-beta 1 GeneSeq Accession R29657 WO9216228, P01137/TGFB1_HUMAN Transforming growth factor beta-1, (SEQ ID NO: 190) TGF-beta 2 GeneSeq Accession R39659 EP542679, P61812/TGFB2_HUMAN Transforming growth factor beta-2, (SEQ ID NO: 191) ZTGF-beta 9 GeneSeq Accession Y70654 WO0015798, SEQ ID NO: 2 of WO0015798, (SEQ ID NO: 192) Anti-TGF beta family antibodies GB2305921 Latent TGF beta binding protein II GeneSeq Accession Y70552 WO0012551, Q14767/LTBP2_HUMAN Latent-transforming growth factor beta-binding protein 2, (SEQ ID NO: 193) MP52 GeneSeq Accession W36100 WO9741250, P43026/GDF5_HUMAN Growth/differentiation factor 5, (SEQ ID NO: 194) b57 Protein GeneSeq Accession W69293 WO9837195, SEQ ID NO: 2 of WO9837195, (SEQ ID NO: 195) Resistin GeneSeq Accession W69293 WO0064920, Q9HD89/RETN_HUMAN Resistin, (isoform 1), (SEQ ID NO: 196) Galectin-4 GeneSeq Accession W11841 WO9703190, P56470/LEG4_HUMAN Galectin-4, (SEQ ID NO: 197) APM-I; ACRP- 30; Famoxin GeneSeq Accession Y71035 W00026363, Q15848/ADIPO_HUMAN Adiponectin, (SEQ ID NO: 198) ACRP-30 Homologue; Complement Component Clq C GeneSeq Accession B30234 WO0063376, P02747/C1QC_HUMAN Complement C1q subcomponent subunit C, (SEQ ID NO: 199) Calpain-10a GeneSeq Accession Y79567 WO0023603, Q9HC96/CAN10_HUMAN Calpain-10, (isoform A), (SEQ ID NO: 200) Calpain-10b GeneSeq Accession Y79568 WO0023603, Q9HC96-2/CAN10_HUMAN Isoform B of Calpain-10, (SEQ ID NO: 201) Calpain-10c GeneSeq Accession Y79569 WO0023603, Q9HC96-3/CAN10_HUMAN Isoform C of Calpain-10, (SEQ ID NO: 202) PDGF-D GeneSeq Accession Y71130 WO0027879, Q9GZP0/PDGFD_HUMAN Platelet-derived growth factor D, (isoform 1), (SEQ ID NO: 203) FasL GeneSeq Accession Y28594 WO9936079, P48023/TNFL6_HUMAN Tumor necrosis factor ligand superfamily member 6, (isoform 1), (SEQ ID NO: 204) Chondro modulin-like protein GeneSeq Accession Y71262 WO0029579, SEQ ID NO: 2 from WO0029579, (SEQ ID NO: 370) Patched GeneSeq Accession W72969 U.S. Pat.
Article Title: Research progress of galectins in glioma.
Article Snippet: :(0123456789) Galectins, which consist of a single polypeptide chain with two CRDs connected by a linker peptide (Galectin-4, -6, -8, -9, and -12); and chimeric Galectin-3, which has a C-terminal CRD rich in proline and glycine and an N-terminal domain that can mediate oligomerization, mainly trimers and pentamers [16].
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.5 Galectin-4/0-Glycan Signaling Promotes SOX9 Expression, Cancer Cell Stemness Properties, and Metastasis Via Activation of RTKs To understand the mechanisms of galectin/glycan signaling for metastasis, we analyzed the genome-wide responsive genes using cDNA microarray by comparing ectopic expression of galectin-4 and control vector in parental cells, LNCaP and 22Rv1, or control and galectin-4 knockdown conditions in 22Rv1-M4 expressing a high level of galectin-4.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: Galectin-4 or LGALS4 NCBI Gene ID: 3960.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.6 Galectin-4 Feed-Forward Upregulates its Binding Sites and Downstream Signaling by Altering the Specific O-Glycosylation Pathway Since galectin-4/SOX9 signaling is dependent on C1GALT1-mediated O-glycosylation and the concomitant overexpression along with PCa progression; we next investigated whether expression of galectin-4, C1GALT1 and protein O-glycosylation may be mutually regulated.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.4 Galectin-4/O-Glycan Signaling Promotes not Only Castration-Resistant Growth but Also Metastasis In Vivo In vivo, downregulation of galectin-4 sensitized the LNCaP-CR4 tumors to castration treatment compared to LNCaP-CR4 control tumors by inhibiting primary tumor growth and lymph node metastasis, suggesting the castration-resistant growth of LNCaP-CR4 had galectin-4 signaling activity (FIG. 4A-C).
Knockdown:Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.7 C1GALT1 and Galectin-4 Expression Exhibit a Synergistic Interaction Resulting in Poor Overall Survival Regarding the critical role of C1GALT1 in mediating galectin-4 signaling in CRPC progression, we next examined the clinical correlation of C1GALT1 and galectin-4 in PCa specimens.
Article Title: Cationic lipids and transfection methods
Article Snippet: No. 7,151,086, (SEQ ID NO: 183) Inhibin alpha GeneSeq Accession B02806 WO0020591, P05111/INHA_HUMAN Inhibin alpha chain, (SEQ ID NO: 184) Inhibin beta GeneSeq Accession H02808 WO0020591, P08476/INHBA_HUMAN Inhibin beta A chain, (SEQ ID NO: 185) P09529/INHBB_HUMAN Inhibin beta B chain, (SEQ ID NO: 186) Cerberus Protein GeneSeq Accession W86032 WO9849296, O95813/CER1_HUMAN Cerberus, (SEQ ID NO: 187) Soluble BMP Receptor Kinase Protein- 3 GeneSeq Accession R95227 WO9614579, Q13873/BMPR2_HUMAN Bone morphogenetic proteinreceptor type-2, (SEQ ID NO: 188) BMP Processing Enzyme Furin GeneSeq Accession W36099 WO9741250, P09958/FURIN_HUMAN Furin, (SEQ ID NO: 189) TGF-beta 1 GeneSeq Accession R29657 WO9216228, P01137/TGFB1_HUMAN Transforming growth factor beta-1, (SEQ ID NO: 190) TGF-beta 2 GeneSeq Accession R39659 EP542679, P61812/TGFB2_HUMAN Transforming growth factor beta-2, (SEQ ID NO: 191) ZTGF-beta 9 GeneSeq Accession Y70654 WO0015798, SEQ ID NO: 2 of WO0015798, (SEQ ID NO: 192) Anti-TGF beta family antibodies GB2305921 Latent TGF beta binding protein II GeneSeq Accession Y70552 WO0012551, Q14767/LTBP2_HUMAN Latent-transforming growth factor beta-binding protein 2, (SEQ ID NO: 193) MP52 GeneSeq Accession W36100 WO9741250, P43026/GDF5_HUMAN Growth/differentiation factor 5, (SEQ ID NO: 194) b57 Protein GeneSeq Accession W69293 WO9837195, SEQ ID NO: 2 of WO9837195, (SEQ ID NO: 195) Resistin GeneSeq Accession W69293 WO0064920, Q9HD89/RETN_HUMAN Resistin, (isoform 1), (SEQ ID NO: 196) Galectin-4 GeneSeq Accession W11841 WO9703190, P56470/LEG4_HUMAN Galectin-4, (SEQ ID NO: 197) APM-I; ACRP- 30; Famoxin GeneSeq Accession Y71035 W00026363, Q15848/ADIPO_HUMAN Adiponectin, (SEQ ID NO: 198) ACRP-30 Homologue; Complement Component Clq C GeneSeq Accession B30234 WO0063376, P02747/C1QC_HUMAN Complement C1q subcomponent subunit C, (SEQ ID NO: 199) Calpain-10a GeneSeq Accession Y79567 WO0023603, Q9HC96/CAN10_HUMAN Calpain-10, (isoform A), (SEQ ID NO: 200) Calpain-10b GeneSeq Accession Y79568 WO0023603, Q9HC96-2/CAN10_HUMAN Isoform B of Calpain-10, (SEQ ID NO: 201) Calpain-10c GeneSeq Accession Y79569 WO0023603, Q9HC96-3/CAN10_HUMAN Isoform C of Calpain-10, (SEQ ID NO: 202) PDGF-D GeneSeq Accession Y71130 WO0027879, Q9GZP0/PDGFD_HUMAN Platelet-derived growth factor D, (isoform 1), (SEQ ID NO: 203) FasL GeneSeq Accession Y28594 WO9936079, P48023/TNFL6_HUMAN Tumor necrosis factor ligand superfamily member 6, (isoform 1), (SEQ ID NO: 204) Chondro modulin-like protein GeneSeq Accession Y71262 WO0029579, SEQ ID NO: 2 from WO0029579, (SEQ ID NO: 370) Patched GeneSeq Accession W72969 U.S. Pat.
Article Title: Research progress of galectins in glioma.
Article Snippet: :(0123456789) Galectins, which consist of a single polypeptide chain with two CRDs connected by a linker peptide (Galectin-4, -6, -8, -9, and -12); and chimeric Galectin-3, which has a C-terminal CRD rich in proline and glycine and an N-terminal domain that can mediate oligomerization, mainly trimers and pentamers [16].
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.5 Galectin-4/0-Glycan Signaling Promotes SOX9 Expression, Cancer Cell Stemness Properties, and Metastasis Via Activation of RTKs To understand the mechanisms of galectin/glycan signaling for metastasis, we analyzed the genome-wide responsive genes using cDNA microarray by comparing ectopic expression of galectin-4 and control vector in parental cells, LNCaP and 22Rv1, or control and galectin-4 knockdown conditions in 22Rv1-M4 expressing a high level of galectin-4.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: Galectin-4 or LGALS4 NCBI Gene ID: 3960.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.6 Galectin-4 Feed-Forward Upregulates its Binding Sites and Downstream Signaling by Altering the Specific O-Glycosylation Pathway Since galectin-4/SOX9 signaling is dependent on C1GALT1-mediated O-glycosylation and the concomitant overexpression along with PCa progression; we next investigated whether expression of galectin-4, C1GALT1 and protein O-glycosylation may be mutually regulated.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.4 Galectin-4/O-Glycan Signaling Promotes not Only Castration-Resistant Growth but Also Metastasis In Vivo In vivo, downregulation of galectin-4 sensitized the LNCaP-CR4 tumors to castration treatment compared to LNCaP-CR4 control tumors by inhibiting primary tumor growth and lymph node metastasis, suggesting the castration-resistant growth of LNCaP-CR4 had galectin-4 signaling activity (FIG. 4A-C).
Binding Assay:Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.7 C1GALT1 and Galectin-4 Expression Exhibit a Synergistic Interaction Resulting in Poor Overall Survival Regarding the critical role of C1GALT1 in mediating galectin-4 signaling in CRPC progression, we next examined the clinical correlation of C1GALT1 and galectin-4 in PCa specimens.
Article Title: Cationic lipids and transfection methods
Article Snippet: No. 7,151,086, (SEQ ID NO: 183) Inhibin alpha GeneSeq Accession B02806 WO0020591, P05111/INHA_HUMAN Inhibin alpha chain, (SEQ ID NO: 184) Inhibin beta GeneSeq Accession H02808 WO0020591, P08476/INHBA_HUMAN Inhibin beta A chain, (SEQ ID NO: 185) P09529/INHBB_HUMAN Inhibin beta B chain, (SEQ ID NO: 186) Cerberus Protein GeneSeq Accession W86032 WO9849296, O95813/CER1_HUMAN Cerberus, (SEQ ID NO: 187) Soluble BMP Receptor Kinase Protein- 3 GeneSeq Accession R95227 WO9614579, Q13873/BMPR2_HUMAN Bone morphogenetic proteinreceptor type-2, (SEQ ID NO: 188) BMP Processing Enzyme Furin GeneSeq Accession W36099 WO9741250, P09958/FURIN_HUMAN Furin, (SEQ ID NO: 189) TGF-beta 1 GeneSeq Accession R29657 WO9216228, P01137/TGFB1_HUMAN Transforming growth factor beta-1, (SEQ ID NO: 190) TGF-beta 2 GeneSeq Accession R39659 EP542679, P61812/TGFB2_HUMAN Transforming growth factor beta-2, (SEQ ID NO: 191) ZTGF-beta 9 GeneSeq Accession Y70654 WO0015798, SEQ ID NO: 2 of WO0015798, (SEQ ID NO: 192) Anti-TGF beta family antibodies GB2305921 Latent TGF beta binding protein II GeneSeq Accession Y70552 WO0012551, Q14767/LTBP2_HUMAN Latent-transforming growth factor beta-binding protein 2, (SEQ ID NO: 193) MP52 GeneSeq Accession W36100 WO9741250, P43026/GDF5_HUMAN Growth/differentiation factor 5, (SEQ ID NO: 194) b57 Protein GeneSeq Accession W69293 WO9837195, SEQ ID NO: 2 of WO9837195, (SEQ ID NO: 195) Resistin GeneSeq Accession W69293 WO0064920, Q9HD89/RETN_HUMAN Resistin, (isoform 1), (SEQ ID NO: 196) Galectin-4 GeneSeq Accession W11841 WO9703190, P56470/LEG4_HUMAN Galectin-4, (SEQ ID NO: 197) APM-I; ACRP- 30; Famoxin GeneSeq Accession Y71035 W00026363, Q15848/ADIPO_HUMAN Adiponectin, (SEQ ID NO: 198) ACRP-30 Homologue; Complement Component Clq C GeneSeq Accession B30234 WO0063376, P02747/C1QC_HUMAN Complement C1q subcomponent subunit C, (SEQ ID NO: 199) Calpain-10a GeneSeq Accession Y79567 WO0023603, Q9HC96/CAN10_HUMAN Calpain-10, (isoform A), (SEQ ID NO: 200) Calpain-10b GeneSeq Accession Y79568 WO0023603, Q9HC96-2/CAN10_HUMAN Isoform B of Calpain-10, (SEQ ID NO: 201) Calpain-10c GeneSeq Accession Y79569 WO0023603, Q9HC96-3/CAN10_HUMAN Isoform C of Calpain-10, (SEQ ID NO: 202) PDGF-D GeneSeq Accession Y71130 WO0027879, Q9GZP0/PDGFD_HUMAN Platelet-derived growth factor D, (isoform 1), (SEQ ID NO: 203) FasL GeneSeq Accession Y28594 WO9936079, P48023/TNFL6_HUMAN Tumor necrosis factor ligand superfamily member 6, (isoform 1), (SEQ ID NO: 204) Chondro modulin-like protein GeneSeq Accession Y71262 WO0029579, SEQ ID NO: 2 from WO0029579, (SEQ ID NO: 370) Patched GeneSeq Accession W72969 U.S. Pat.
Article Title: Research progress of galectins in glioma.
Article Snippet: :(0123456789) Galectins, which consist of a single polypeptide chain with two CRDs connected by a linker peptide (Galectin-4, -6, -8, -9, and -12); and chimeric Galectin-3, which has a C-terminal CRD rich in proline and glycine and an N-terminal domain that can mediate oligomerization, mainly trimers and pentamers [16].
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.5 Galectin-4/0-Glycan Signaling Promotes SOX9 Expression, Cancer Cell Stemness Properties, and Metastasis Via Activation of RTKs To understand the mechanisms of galectin/glycan signaling for metastasis, we analyzed the genome-wide responsive genes using cDNA microarray by comparing ectopic expression of galectin-4 and control vector in parental cells, LNCaP and 22Rv1, or control and galectin-4 knockdown conditions in 22Rv1-M4 expressing a high level of galectin-4.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: Galectin-4 or LGALS4 NCBI Gene ID: 3960.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.6 Galectin-4 Feed-Forward Upregulates its Binding Sites and Downstream Signaling by Altering the Specific O-Glycosylation Pathway Since galectin-4/SOX9 signaling is dependent on C1GALT1-mediated O-glycosylation and the concomitant overexpression along with PCa progression; we next investigated whether expression of galectin-4, C1GALT1 and protein O-glycosylation may be mutually regulated.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.4 Galectin-4/O-Glycan Signaling Promotes not Only Castration-Resistant Growth but Also Metastasis In Vivo In vivo, downregulation of galectin-4 sensitized the LNCaP-CR4 tumors to castration treatment compared to LNCaP-CR4 control tumors by inhibiting primary tumor growth and lymph node metastasis, suggesting the castration-resistant growth of LNCaP-CR4 had galectin-4 signaling activity (FIG. 4A-C).
Over Expression:Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.7 C1GALT1 and Galectin-4 Expression Exhibit a Synergistic Interaction Resulting in Poor Overall Survival Regarding the critical role of C1GALT1 in mediating galectin-4 signaling in CRPC progression, we next examined the clinical correlation of C1GALT1 and galectin-4 in PCa specimens.
Article Title: Cationic lipids and transfection methods
Article Snippet: No. 7,151,086, (SEQ ID NO: 183) Inhibin alpha GeneSeq Accession B02806 WO0020591, P05111/INHA_HUMAN Inhibin alpha chain, (SEQ ID NO: 184) Inhibin beta GeneSeq Accession H02808 WO0020591, P08476/INHBA_HUMAN Inhibin beta A chain, (SEQ ID NO: 185) P09529/INHBB_HUMAN Inhibin beta B chain, (SEQ ID NO: 186) Cerberus Protein GeneSeq Accession W86032 WO9849296, O95813/CER1_HUMAN Cerberus, (SEQ ID NO: 187) Soluble BMP Receptor Kinase Protein- 3 GeneSeq Accession R95227 WO9614579, Q13873/BMPR2_HUMAN Bone morphogenetic proteinreceptor type-2, (SEQ ID NO: 188) BMP Processing Enzyme Furin GeneSeq Accession W36099 WO9741250, P09958/FURIN_HUMAN Furin, (SEQ ID NO: 189) TGF-beta 1 GeneSeq Accession R29657 WO9216228, P01137/TGFB1_HUMAN Transforming growth factor beta-1, (SEQ ID NO: 190) TGF-beta 2 GeneSeq Accession R39659 EP542679, P61812/TGFB2_HUMAN Transforming growth factor beta-2, (SEQ ID NO: 191) ZTGF-beta 9 GeneSeq Accession Y70654 WO0015798, SEQ ID NO: 2 of WO0015798, (SEQ ID NO: 192) Anti-TGF beta family antibodies GB2305921 Latent TGF beta binding protein II GeneSeq Accession Y70552 WO0012551, Q14767/LTBP2_HUMAN Latent-transforming growth factor beta-binding protein 2, (SEQ ID NO: 193) MP52 GeneSeq Accession W36100 WO9741250, P43026/GDF5_HUMAN Growth/differentiation factor 5, (SEQ ID NO: 194) b57 Protein GeneSeq Accession W69293 WO9837195, SEQ ID NO: 2 of WO9837195, (SEQ ID NO: 195) Resistin GeneSeq Accession W69293 WO0064920, Q9HD89/RETN_HUMAN Resistin, (isoform 1), (SEQ ID NO: 196) Galectin-4 GeneSeq Accession W11841 WO9703190, P56470/LEG4_HUMAN Galectin-4, (SEQ ID NO: 197) APM-I; ACRP- 30; Famoxin GeneSeq Accession Y71035 W00026363, Q15848/ADIPO_HUMAN Adiponectin, (SEQ ID NO: 198) ACRP-30 Homologue; Complement Component Clq C GeneSeq Accession B30234 WO0063376, P02747/C1QC_HUMAN Complement C1q subcomponent subunit C, (SEQ ID NO: 199) Calpain-10a GeneSeq Accession Y79567 WO0023603, Q9HC96/CAN10_HUMAN Calpain-10, (isoform A), (SEQ ID NO: 200) Calpain-10b GeneSeq Accession Y79568 WO0023603, Q9HC96-2/CAN10_HUMAN Isoform B of Calpain-10, (SEQ ID NO: 201) Calpain-10c GeneSeq Accession Y79569 WO0023603, Q9HC96-3/CAN10_HUMAN Isoform C of Calpain-10, (SEQ ID NO: 202) PDGF-D GeneSeq Accession Y71130 WO0027879, Q9GZP0/PDGFD_HUMAN Platelet-derived growth factor D, (isoform 1), (SEQ ID NO: 203) FasL GeneSeq Accession Y28594 WO9936079, P48023/TNFL6_HUMAN Tumor necrosis factor ligand superfamily member 6, (isoform 1), (SEQ ID NO: 204) Chondro modulin-like protein GeneSeq Accession Y71262 WO0029579, SEQ ID NO: 2 from WO0029579, (SEQ ID NO: 370) Patched GeneSeq Accession W72969 U.S. Pat.
Article Title: Research progress of galectins in glioma.
Article Snippet: :(0123456789) Galectins, which consist of a single polypeptide chain with two CRDs connected by a linker peptide (Galectin-4, -6, -8, -9, and -12); and chimeric Galectin-3, which has a C-terminal CRD rich in proline and glycine and an N-terminal domain that can mediate oligomerization, mainly trimers and pentamers [16].
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.5 Galectin-4/0-Glycan Signaling Promotes SOX9 Expression, Cancer Cell Stemness Properties, and Metastasis Via Activation of RTKs To understand the mechanisms of galectin/glycan signaling for metastasis, we analyzed the genome-wide responsive genes using cDNA microarray by comparing ectopic expression of galectin-4 and control vector in parental cells, LNCaP and 22Rv1, or control and galectin-4 knockdown conditions in 22Rv1-M4 expressing a high level of galectin-4.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: Galectin-4 or LGALS4 NCBI Gene ID: 3960.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.6 Galectin-4 Feed-Forward Upregulates its Binding Sites and Downstream Signaling by Altering the Specific O-Glycosylation Pathway Since galectin-4/SOX9 signaling is dependent on C1GALT1-mediated O-glycosylation and the concomitant overexpression along with PCa progression; we next investigated whether expression of galectin-4, C1GALT1 and protein O-glycosylation may be mutually regulated.
Article Title: Biomarkers for predicting prostate cancer progression
Article Snippet: 2.4 Galectin-4/O-Glycan Signaling Promotes not Only Castration-Resistant Growth but Also Metastasis In Vivo In vivo, downregulation of galectin-4 sensitized the LNCaP-CR4 tumors to castration treatment compared to LNCaP-CR4 control tumors by inhibiting primary tumor growth and lymph node metastasis, suggesting the castration-resistant growth of LNCaP-CR4 had galectin-4 signaling activity (FIG. 4A-C).
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